Convenience: No Refrigeration Needed! Ortho Biotic has been scientifically formulated for room temperature storage. Ortho Biotic is carefully handled and manufactured often throughout the year, ensuring optimal product freshness for maximized potency at ingestion. Ortho Biotic is formulated with Saccharomyces boulardii, a proven potentiator for good bacteria that removes pathogens from the gut. This action enables a more effective probiotic presence, encouraging a healthy environment for vitamin uptake and immune support.